gene_symbol
BIRC5
hgnc_id
HGNC:593
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The adenovirus replicates only in cells with active survivin (BIRC5) promoter, leading to selective viral replication and lytic oncolysis of those cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Transcriptional targeting: viral replication driven by survivin promoter activity in tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05139056
disease_id_num_tar_ref
5878
drug_id_num_tar_ref
15957