gene_symbol
UNKNOWN
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
HSPGs function as entry/attachment receptors for the pk7-modified adenovirus; cell killing occurs only when survivin (BIRC5) promoter activity enables viral replication and oncolysis. HSPG expression alone is insufficient for cytotoxicity.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CAR-independent entry via pk7 polylysine fiber binding to HSPG
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05139056
disease_id_num_tar_ref
5878
drug_id_num_tar_ref
15957