gene_symbol
CEACAM5
hgnc_id
HGNC:1817
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
BGB-B167 binds CEA on tumor cells and 4-1BB on T/NK cells, providing localized 4-1BB costimulation that activates cytotoxic lymphocytes to lyse CEA-expressing cells (perforin/granzyme-mediated killing).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Tumor-associated antigen on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05644626
disease_id_num_tar_ref
5889
drug_id_num_tar_ref
15979