gene_symbol
TNFRSF9
hgnc_id
HGNC:11924
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
BGB-B167 crosslinks CEA on tumor cells with 4-1BB on T/NK cells to provide localized 4-1BB costimulation, boosting T-cell cytotoxicity against CEA+ tumor cells. 4-1BB–expressing immune cells are not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
On
other_modifier
Costimulatory receptor agonism; activation gated by CEA-dependent crosslinking in the tumor microenvironment
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05644626
disease_id_num_tar_ref
5889
drug_id_num_tar_ref
15979