gene_symbol
TPBG
hgnc_id
HGNC:12004
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-5T4 Fab targets 5T4+ cells and presents a superantigen (SEA/E-120) that engages TCR Vβ (with MHC II), polyclonally activating T cells to kill 5T4-expressing tumor cells via cytotoxic T-cell mechanisms.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Tumor-associated oncofetal antigen expressed on many carcinomas
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05894447
disease_id_num_tar_ref
5894
drug_id_num_tar_ref
15989