gene_symbol
TRB
hgnc_id
HGNC:12155
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The SEA/E superantigen binds TCR Vβ on T cells and MHC II to polyclonally activate T cells, which then kill 5T4-expressing tumor cells (perforin/granzyme). TCR Vβ+ cells are engaged/activated, not directly killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds multiple TRBV families to polyclonally activate T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05894447
disease_id_num_tar_ref
5894
drug_id_num_tar_ref
15989