gene_symbol
UNKNOWN
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The superantigen moiety binds MHC class II to help activate T cells (via TCR Vβ), but the activated T cells are directed to kill 5T4-positive tumor cells bound by the anti-5T4 Fab; MHC II–expressing cells are not the intended cytotoxic targets.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Superantigen engagement of MHC class II on antigen-presenting cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05894447
disease_id_num_tar_ref
5894
drug_id_num_tar_ref
15989