gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Obinutuzumab binds CD20 on B cells and, via enhanced FcγRIIIa engagement, triggers NK cell–mediated ADCC and macrophage ADCP; it also induces direct, caspase‑independent cell death of CD20+ cells (with limited CDC).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II anti-CD20 epitope; drives B-cell depletion via direct cell death and enhanced ADCC/ADCP
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05894447
disease_id_num_tar_ref
5894
drug_id_num_tar_ref
15991