gene_symbol
FCGR3B
hgnc_id
HGNC:3620
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Obinutuzumab binds CD20 on B cells; its Fc engages FcγRIII receptors (including CD16b on neutrophils) to recruit effector functions (ADCC/ADCP), causing death of CD20+ B cells. The CD16b-expressing cells are effectors, not the cells killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Afucosylated Fc increases affinity; contributes to effector functions
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05894447
disease_id_num_tar_ref
5894
drug_id_num_tar_ref
15991