gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Nimotuzumab (IgG1) binds EGFR on target cells and its Fc engages Fcγ receptors on immune effectors (e.g., NK cells), triggering ADCC (± some CDC), leading to lysis of EGFR+ cells; EGFR blockade also suppresses survival signaling.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds EGFR extracellular domain; blocks ligand binding; IgG1 Fc can engage Fc gamma receptors for ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06509009
disease_id_num_tar_ref
5896
drug_id_num_tar_ref
15995