gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
TCR-engineered T cells kill only cells presenting the NY-ESO-1 peptide in HLA-A2 via perforin/granzyme after TCR engagement; HLA-A2 expression alone is insufficient for killing.
enzyme_product
Off
epitope
Off
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Restriction element presenting NY-ESO-1 peptide to the engineered TCR
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05989828
disease_id_num_tar_ref
54
drug_id_num_tar_ref
130