gene_symbol
IL5RA
hgnc_id
HGNC:6017
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Benralizumab binds IL-5Rα on eosinophils/basophils and its afucosylated IgG1 Fc engages FcγRIIIa on NK cells to induce antibody-dependent cellular cytotoxicity (ADCC), leading to apoptosis and depletion of the target cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06427876
disease_id_num_tar_ref
5898
drug_id_num_tar_ref
16001