gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Benralizumab binds IL-5Rα on eosinophils/basophils and uses its Fc to engage FcγRIIIa (CD16a) on NK cells, triggering ADCC to kill the IL-5Rα+ cells; CD16a+ NK cells are effectors, not targets.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated engagement to trigger ADCC; enhanced by afucosylation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06427876
disease_id_num_tar_ref
5898
drug_id_num_tar_ref
16001