gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The CD20×CD3 bispecific links T cells to CD20+ cells, forming an immune synapse and activating T cells to release perforin and granzymes, causing lysis/apoptosis of the CD20-expressing cells (MHC-independent).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
2:1 bispecific format includes two CD20-binding arms
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06192888
disease_id_num_tar_ref
5900
drug_id_num_tar_ref
16005