gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Tarlatamab binds CD3 on T cells and DLL3 on tumor cells to activate T cells, which kill DLL3+ tumor cells via perforin/granzyme and cytokine-mediated cytotoxicity; CD3+ T cells are not killed.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CD3 antigen on T cells; epsilon chain
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06117774
disease_id_num_tar_ref
5902
drug_id_num_tar_ref
16009