gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
After the ADC binds TROP-2 and is internalized, it releases SN-38, which inhibits DNA topoisomerase I, stabilizing topo I–DNA complexes and causing DNA damage and apoptosis (with possible bystander killing).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Target of SN-38 payload
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06123468
disease_id_num_tar_ref
5904
drug_id_num_tar_ref
16015