gene_symbol
ERBB3
hgnc_id
HGNC:3431
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The bispecific ADC binds HER3 on target cells, is internalized, and releases the topoisomerase I inhibitor brengitecan, causing DNA damage and cell death (with potential bystander effect).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC antigen target
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06405425
disease_id_num_tar_ref
5910
drug_id_num_tar_ref
16030