gene_symbol
IL18R1
hgnc_id
HGNC:5988
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The CAR-T cells kill CD19+ targets via CAR-mediated T-cell cytolysis. Secreted IL-18 binds IL-18Rα to activate immune cells and enhance responses, but IL-18Rα-expressing cells are not targeted or directly killed by the therapy.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Primary binding chain for IL-18; forms signaling complex with IL18RAP
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05989204
disease_id_num_tar_ref
5911
drug_id_num_tar_ref
16032