gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-HER2 ADC binds HER2, is internalized, and releases MMAE after linker cleavage; MMAE disrupts microtubules causing G2/M arrest and apoptosis, with possible bystander killing due to membrane-permeable payload.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface receptor tyrosine kinase targeted by the antibody component
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06650332
disease_id_num_tar_ref
499
drug_id_num_tar_ref
1381