gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Adoptively transferred neoantigen-specific T cells recognize the patient-specific peptide–MHC II via their TCR and directly kill target cells through perforin/granzyme release and Fas–FasL-mediated apoptosis.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
CD4+ TCR recognition; HLA-DR/DP/DQ restricted; multiple patient-unique neoepitopes
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05685004
disease_id_num_tar_ref
5914
drug_id_num_tar_ref
16038