gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Cetuximab binds EGFR on tumor cells and its IgG1 Fc engages Fcγ receptor–bearing effector cells (e.g., NK cells) to mediate ADCC (and possibly CDC), killing EGFR+ cells; EGFR signaling blockade is mainly cytostatic.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain (domain III) to block ligand binding and receptor dimerization; IgG1 Fc can engage Fcγ receptors for ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06231017
disease_id_num_tar_ref
5917
drug_id_num_tar_ref
16045