gene_symbol
ERBB3
hgnc_id
HGNC:3431
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds HER3 on tumor cells, is internalized, and releases a topoisomerase I–inhibitor payload that causes DNA damage, cell‑cycle arrest, and apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Antibody moiety of ADC; targets HER3 on tumor cells for internalization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06170190
disease_id_num_tar_ref
5921
drug_id_num_tar_ref
16055