gene_symbol
BCL2
hgnc_id
HGNC:990
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Venetoclax is a BH3 mimetic that binds and inhibits BCL-2, releasing pro-apoptotic effectors (BAX/BAK) to trigger mitochondrial outer membrane permeabilization, caspase activation, and apoptosis in BCL-2–dependent cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
BH3 mimetic; binds the hydrophobic BH3-binding groove of BCL-2
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06109064
disease_id_num_tar_ref
5923
drug_id_num_tar_ref
16058