gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD19 CAR T cells bind CD19 and, via CD3z and costimulatory signaling, activate cytotoxic T-cell effector functions to kill CD19+ cells through perforin/granzyme-mediated cytolysis and death receptor-mediated apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
HLA-independent recognition of cell-surface B-cell antigen
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06271057
disease_id_num_tar_ref
5932
drug_id_num_tar_ref
16078