gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
TCR recognition of the tumor peptide–HLA-A class I complex activates the reinfused T cells, which kill target cells via perforin/granzyme-mediated lysis and Fas–FasL–induced apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
peptide–MHC class I complex; patient-specific epitope; CD8+ T-cell restricted
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06431100
disease_id_num_tar_ref
5936
drug_id_num_tar_ref
16089