gene_symbol
HLA-C
hgnc_id
HGNC:4933
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Tumor-reactive TCR T cells recognize the tumor peptide–HLA-C complex via their TCR and directly induce target-cell death via perforin/granzyme-mediated apoptosis (and Fas–FasL signaling).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
peptide–MHC class I complex; patient-specific epitope; CD8+ T-cell restricted
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06431100
disease_id_num_tar_ref
5936
drug_id_num_tar_ref
16089