gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds HER2, is internalized, and releases MMAE to disrupt microtubules causing G2/M arrest and apoptosis; Fc can also trigger ADCC against HER2+ cells.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain of HER2; ADC internalized and releases MMAE; Fc can mediate ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06185400
disease_id_num_tar_ref
502
drug_id_num_tar_ref
1393