gene_symbol
HLA-DQB1
hgnc_id
HGNC:4944
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Infused tumor-reactive T cells recognize the tumor peptide–HLA-DQ complex via their native TCRs and directly kill target cells through perforin/granzyme release and Fas–FasL–mediated apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
peptide–MHC class II complex; patient-specific epitope; CD4+ T-cell restricted
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06431100
disease_id_num_tar_ref
5936
drug_id_num_tar_ref
16089