gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Cevostamab links CD3 on T cells to FcRH5 on myeloma cells, activating T-cell cytotoxicity (perforin/granzyme-mediated killing) against FcRH5+ tumor cells; CD3E-expressing T cells are not targeted for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Subunit of the T-cell receptor CD3 complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05646836
disease_id_num_tar_ref
5938
drug_id_num_tar_ref
16093