gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CD19-directed CAR-T cells bind CD19 on target cells and induce killing via T-cell cytotoxicity (perforin/granzyme-mediated apoptosis and related immune effector mechanisms).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
FMC63 scFv-defined extracellular epitope; HLA-independent recognition
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05400109
disease_id_num_tar_ref
5951
drug_id_num_tar_ref
16134