gene_symbol
CD274
hgnc_id
HGNC:17635
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
By blocking PD‑L1, the drug reverses PD‑1/PD‑L1 checkpoint inhibition, enabling cytotoxic T cells to kill PD‑L1–expressing tumor cells; additionally, its CD47 blockade promotes macrophage-mediated phagocytosis of PD‑L1/CD47 double‑positive cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Higher-affinity binding relative to CD47; blocks PD-1/PD-L1 interaction
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05991180
disease_id_num_tar_ref
5963
drug_id_num_tar_ref
16173