gene_symbol
CD47
hgnc_id
HGNC:1682
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Blocking CD47–SIRPα removes the don’t-eat-me signal on CD47+ tumor cells, enabling Fc/FcγR-dependent macrophage-mediated phagocytosis; additionally, PD-L1 blockade restores T-cell killing of PD-L1/CD47 double-positive cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Lower-affinity binding; disrupts CD47–SIRPalpha signaling to enhance phagocytosis
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05991180
disease_id_num_tar_ref
5963
drug_id_num_tar_ref
16173