gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds TROP-2 on target cells, is internalized, and releases SN-38 after linker cleavage; SN-38 inhibits topoisomerase I, causing DNA strand breaks and apoptosis (with possible bystander killing due to payload permeability).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface antigen bound by the ADC to enable internalization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06528483
disease_id_num_tar_ref
5970
drug_id_num_tar_ref
16189