gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
LM-302 binds CLDN18.2 on tumor cells, is internalized, and releases MMAE; MMAE binds beta-tubulin to block microtubule polymerization, causing G2/M arrest and apoptosis in CLDN18.2-positive cells. Beta-tubulin expression alone does not determine killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
MMAE payload binds the vinca domain to inhibit microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05934331
disease_id_num_tar_ref
5973
drug_id_num_tar_ref
16195