gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Autologous CRISPR-edited TILs recognize the neoantigen–HLA class I complex via their TCR and directly lyse target cells through perforin/granzyme-mediated apoptosis, with IFN-γ/Fas–FasL contributions.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
TCR-dependent; CD8-restricted; HLA-A/HLA-B/HLA-C
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06145802
disease_id_num_tar_ref
5975
drug_id_num_tar_ref
16207