gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Small-molecule TKI covalently inhibits EGFR kinase (Cys797), blocking EGFR phosphorylation and downstream MAPK/PI3K–AKT signaling, causing growth arrest and apoptosis of EGFR-mutant (incl. T790M) tumor cells.
enzyme_product
On
epitope
Off
variant
On
isoform
Off
hla_specific
Off
gated
Off
other_modifier
EGFR L858R (p.Leu858Arg) activating mutation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06185400
disease_id_num_tar_ref
502
drug_id_num_tar_ref
1395