gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
HER2-binding ADC is internalized into HER2+ cells; linker cleavage releases a camptothecin-derived topoisomerase I inhibitor that causes DNA breaks, leading to apoptosis and growth inhibition.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
HER2 receptor tyrosine kinase on tumor cells targeted by trastuzumab antibody moiety
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05671822
disease_id_num_tar_ref
5997
drug_id_num_tar_ref
16271