gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds HER2 (not topoisomerase I), is internalized, then releases a camptothecin-derived topoisomerase I inhibitor that causes DNA breaks and apoptosis in HER2-positive cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Camptothecin-derived payload (rezetecan) stabilizes TOP1–DNA cleavage complexes
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05671822
disease_id_num_tar_ref
5997
drug_id_num_tar_ref
16271