gene_symbol
CLDN18
hgnc_id
HGNC:2039
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
AK132 binds CLDN18.2 on tumor cells and locally blocks CD47–SIRPα, removing the “don’t eat me” signal and enabling Fc-dependent macrophage-mediated phagocytosis (ADCP) of CLDN18.2+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
A2 isoform of Claudin-18; tumor-associated tight junction protein
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06166472
disease_id_num_tar_ref
5998
drug_id_num_tar_ref
16277