gene_symbol
CD47
hgnc_id
HGNC:1682
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
AK132 focuses killing on CLDN18.2-positive tumor cells by blocking CD47–SIRPα to enable macrophage-mediated phagocytosis (and possible Fc effector functions); CD47 alone is not a cytotoxic target.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
On
other_modifier
Checkpoint receptor; CD47–SIRPα axis blockade focused to CLDN18.2+ cells via bispecific design
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06166472
disease_id_num_tar_ref
5998
drug_id_num_tar_ref
16277