gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Irreversible covalent inhibition of mutant EGFR (including T790M) at the ATP site blocks EGFR autophosphorylation and downstream MAPK/PI3K–AKT signaling, leading to growth arrest and apoptosis of EGFR-mutant tumor cells.
enzyme_product
On
epitope
Off
variant
On
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Irreversible covalent inhibitor binding Cys797 in the ATP site; mutant-selective
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06185400
disease_id_num_tar_ref
502
drug_id_num_tar_ref
1396