gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Osimertinib covalently inhibits mutant EGFR (Ex19del) kinase activity, blocking MAPK/ERK and PI3K/AKT survival signaling and inducing tumor cell apoptosis.
enzyme_product
Off
epitope
Off
variant
On
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Irreversible covalent binding to kinase domain Cys797; mutant-selective EGFR TKI
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05801029
disease_id_num_tar_ref
6005
drug_id_num_tar_ref
16292