gene_symbol
CD47
hgnc_id
HGNC:1682
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IMM2520 binds CD47 on target cells, blocking CD47–SIRPα “don’t‑eat‑me” signaling and engaging Fcγ receptors to drive macrophage-mediated phagocytosis (ADCP) and NK-cell ADCC, leading to death of CD47+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
phagocytosis checkpoint ligand
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05780307
disease_id_num_tar_ref
6009
drug_id_num_tar_ref
16299