gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-HER2 ADC binds HER2, is internalized, and releases a camptothecin-derived topoisomerase I inhibitor that causes DNA damage and apoptosis; the IgG1 may also induce Fc-mediated ADCC.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
surface receptor targeted by trastuzumab moiety; internalization enables payload release
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05824325
disease_id_num_tar_ref
6023
drug_id_num_tar_ref
16332