gene_symbol
IL5RA
hgnc_id
HGNC:6017
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Benralizumab binds IL-5Rα on eosinophils/basophils and engages NK cells via its afucosylated Fc (FcγRIIIa), triggering potent antibody-dependent cellular cytotoxicity (ADCC) that kills the target cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Alpha subunit of IL-5 receptor on eosinophils and basophils; benralizumab binding triggers NK cell–mediated ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06456450
disease_id_num_tar_ref
6024
drug_id_num_tar_ref
16336