gene_symbol
MET
hgnc_id
HGNC:7029
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Amivantamab binds MET on tumor cells and engages Fc receptors on immune effectors to mediate Fc-dependent ADCC and ADCP, leading to killing of MET-expressing cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain of wild-type and certain mutant forms; blocks ligand binding and receptor phosphorylation; induces receptor internalization/degradation; mediates Fc-dependent ADCC/ADCP
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06784791
disease_id_num_tar_ref
507
drug_id_num_tar_ref
1406