gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
MYTX-011 binds c-MET on tumor cells; after internalization it releases MMAE, which inhibits tubulin polymerization to kill the c-MET–positive cells. Tubulin beta is not the binding target, so tubulin-expressing cells are not directly targeted by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
MMAE payload binds the vinca site to inhibit polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05652868
disease_id_num_tar_ref
6026
drug_id_num_tar_ref
16340