gene_symbol
FLT1
hgnc_id
HGNC:3763
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
VEGFR1-specific CAR-T cells bind VEGFR1 on target cells, activate, and kill via T-cell cytotoxic pathways (perforin/granzyme and Fas–FasL), with supportive cytokine-mediated effects.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface receptor tyrosine kinase (a.k.a. FLT1); CAR binds extracellular domain
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05477927
disease_id_num_tar_ref
6042
drug_id_num_tar_ref
16378