gene_symbol
CD274
hgnc_id
HGNC:17635
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-T cells bind PD-L1 and are activated to kill PD-L1+ cells via perforin/granzyme-mediated cytolysis and apoptotic death ligand pathways, with cytokine release.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Immune checkpoint ligand (B7-H1); CAR binds extracellular domain
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05477927
disease_id_num_tar_ref
6042
drug_id_num_tar_ref
16378