gene_symbol
CLDN18
hgnc_id
HGNC:2039
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds CLDN18.2 on tumor cells and recruits immune effector functions—Fc-mediated ADCC (e.g., NK cells) and complement-dependent cytotoxicity (CDC)—to lyse target-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
Stomach-specific isoform 2 of claudin-18
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06093425
disease_id_num_tar_ref
6044
drug_id_num_tar_ref
16380